A wide variety of atomizers and nozzles, among others, electrospray, air-atomizing, and ultrasonic nozzles can be tested in our environmental controlled laboratory. Depending on the customer requirements testing is performed in a cleanroom (10.000 or higher) Our laboratory includes a 10.000 clean room) equipped with particle-controlled enclosures such as glove boxes, isolators, and fume hoods. Materials to be sprayed include a variety of chemicals, biomaterials, drugs, polymer compositions, and nanoparticles (e.g., CNT's).
Testing and Validation Services
Testing of spray nozzles and atomizers
Pattern and plume characterization tests using Spray Error Patternation (SEP) and Digital Image Microscopy (DIM).
Particle/droplet size distribution analysis using Helos BF (Sympatec) particle size analyzer.
Documentation incl. Spray Error Patternation, Spray Symmetry, Spray Geometry, Droplet/Particle Size Distribution.
In-vitro testing of inhalers and nasal pump sprays
Shot Weight using analytical micro balance.
Spray Pattern and plume characterization tests using SEP instrumentation and Digital Image Microscopy (DIM)
Particle/droplet size distribution using Helos BF (Sympatec).
Documentation incl. Spray Error Patternation, Spray Symmetry, Spray Geometry, Droplet/Particle Size Distribution.
Nozzle Validation
Validation of spray nozzles using customer specified materials, (e.g., polymers, nanomaterials, drugs, solvents).
Validation of coating nozzles by performing coating trials according to Customer Specifications with SEPPAT instrumentation. Evaluating of test results, such as quality and weight of coated samples, using Digital Microscopy and microbalances.
Validation services based on GAMP guidelines, e.g., URS User Requirement Specificatiion, IQ-OQ Installation and Operational Qualification, and SAT Site Acceptance Tests.
Process Validation
Review of spraying process may include fine-tuning of operating parameters and liquid supply/tubing setup.
Best practices such as cleaning methods, procedures for air bubbles, pulsation, and clogging prevention, Reference Pattern generation, and adapting the SEP method to your requirements.
Research & Development Services
Development of improved inhalers and spray nozzles customized for the particular application using our Design and Analysis (Autodesk Inventor), Predictive Engineering (CF Design), Software & Electrical Engineering, Computer Aided Manufacturing (EdgeCam), and Micro Machining platform.
Training and Consulting
On-site customized training for best practices related to, among others, the integration and use of the SEP instrumentation and software. ioos provides consulting services, beginning from nozzle development, to spray testing and process validation.